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Don't be afraid to ask questions.
If you don't understand, ask your doctor to repeat it or write it down.
If you are prescribed a drug, make sure you know why it has been given to you, how long to take it for etc. Remember pharmacists are experts in medication and a very useful source of advice.
Be direct. If you have a problem that you find embarrassing or difficult to talk about, don't leave it to the end of the appointment before mentioning it. Remember your problem is likely to a common one for your GP, who is there to help you.